BI836845 in women with Breast Cancer Health Research Authority

Decreased bone mineral density (a measurement of bone strength),meaning thinner, weaker bones that are more likely to break. It’s usually diagnosed with a bone density scan (often called a DEXA scan). To help keep your bones healthy you can increase your intake of calcium and vitamin D.

Some people start taking exemestane after a few years of taking the hormone therapy drug tamoxifen. Most women with breast cancer will go on a course of drugs to treat the cancer and reduce the likelihood of it coming back, even if they have already had surgery and/or radiotherapy. The aim of this trial is to compare exemestane alone with abiraterone and exemestane.

Exemestane 25mg tablets (Aromasin®)

Getting pregnant while taking exemestane is not recommended. Taking exemestane while pregnant may be harmful to a developing baby. It’s possible to become pregnant while taking exemestane even if your periods have stopped with ovarian suppression. The recommended length of time that exemestane is taken for will depend on your individual situation. Exemestane is taken as a tablet once a day, with or without food. Exemestane works by reducing the amount of oestrogen made in the body.

Exemestane is a hormone therapy, also known by its brand name Aromasin. Find out how it’s prescribed, how it works and the potential side effects. It’s a worrying time for many people and we want to be there for you whenever – and wherever – you need us.

Medicine safety

Moreover, AI therapy has been demonstrated to reduce the rate of mortality in breast cancer by up to 40% [3]. However, as we will see in the next section, joint pain is one of the most common side effects. Exemestane is used to treat breast cancer in women who are postmenopausal, either naturally, or as a result of medical treatment.

• Blocking the effects of these hormones can treat breast cancer.
• If you think your order may be subject to additional charges, you can contact us to find out exact charges for your order.
• These guidelines help to identify those who need to have a bone density scan and treatment for osteoporosis.
• It most commonly occurs when changing from one hormone therapy to another.

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In advanced breast cancer, the cancer cells may grow more slowly or stop growing completely. Some breast cancer treatments can increase your risk of osteoporosis and broken bones. Overall, the beneficial effect of exemestane over tamoxifen with respect to DFS was apparent regardless of nodal status or prior chemotherapy or hormonal therapy. Statistical significance was not maintained in a few sub-groups with small sample sizes. These showed a trend favouring exemestane in patients with more than 9 nodes positive, or previous chemotherapy CMF. In patients with nodal status unknown, previous chemotherapy other, as well as unknown/missing status of previous hormonal therapy a non statistically significant trend favouring tamoxifen was observed.

Exemestane 25mg Film-coated Tablets

Cancer Chat is our fully moderated forum where you can talk to others affected by cancer, share experiences, and get support. We know that it is common to struggle with your mental health when you have cancer or care for someone with cancer. It’s important to use contraception while taking this drug if you have the potential to become pregnant. If it is unclear if you have been through the menopause you will also need to use contraception whilst taking exemestane. Blood tests can also check any changes to the liver enzymes in your body. If you have difficulty sleeping, it can help to change a few things about how you try to sleep.

We are unable to list all the possible interactions that may happen. An example is grapefruit or grapefruit juice which can increase the side effects of certain drugs. Increased risk of getting an infection is due to a drop in white blood cells. Symptoms include Buy steriods online uk a change in temperature, aching muscles, headaches, feeling cold and shivery and generally unwell. You might have other symptoms depending on where the infection is. This process is called aromatisation and happens mainly in the fatty tissues, muscle and skin.

Two out of three breast cancers are ‘oestrogen receptor positive’. This means the cancer may be sensitive to changes in levels of the hormone oestrogen. But sometimes the cancer starts to grow again and then doctors may use exemestane. The suggested cause of joint pain is the drop in circulating oestrogens by aromatase inhibition in  postmenopausal women. Joint pain, or arthralgia, appears to be a relatively common side effect.